Hufner wins final luge World Cup meet

SOCHI, Russia (AP) — Olympic luge champion Tatjana Hufner edged out two other Germans to win the women's singles in the final World Cup meet of the season, a test event for the Sochi Winter Games next year.

Natalie Geisenberger, the current world champion and Olympic bronze medalist, finished second in Saturday's meet, but had already won the overall World Cup before the competition started. Anke Wischnewski was third.

Geisenberger had the fastest time of the day at 50.894 seconds in the first run, but Hufner's two-run combined time of 1 minute 41.922 seconds was 0.038 faster. Wischnewski placed second in the overall World Cup standings and Hufner was third.

Although bobsledders and skeleton riders had expressed dissatisfaction with the ice quality at the Sanki track earlier in February, Saturday's sliders praised the conditions.

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FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Adele, 'Les Miserables' cast sing on Oscar stage

LOS ANGELES (AP) — It was an extra starry, musical day at the Dolby Theatre.

Adele took the stage first Friday, followed by the cast of "Les Miserables," singing together of the first time.

Oscar nominees Hugh Jackman and Anne Hathaway, along with co-stars Russell Crowe, Amanda Seyfried, Helena Bonham-Carter, Sasha Baron-Cohen, Eddie Redmayne, Aaron Tveit and Samantha Barks rehearsed their performances on the Oscar stage. They were backed by members of the musical's stage productions from London and Broadway.

"Les Miserables" director Tom Hooper sat in the front row of the theater as his cast sang.

Moments earlier, Adele dazzled the tiny audience of show workers with her performance of the James Bond theme "Skyfall."

"I need a lot more reverb on me," she said after her first run. "You might need to get a new reverb machine."

The 24-year-old multiple Grammy winner arrived wearing a black tunic, black leggings and flats, with no makeup and her hair in a ponytail.

"I'm going to have very high heels on the night, guys," she announced from the microphone, sipping tea between verses.

"Do you need the dresses?" she asked, and a team of stylists brought out the gowns Adele is considering for her Oscar performance.

The dress producers favored? "It's very heavy — I mean I struggle to stand in it," Adele said. "Come and feel how heavy it is, so you don't think I'm a wimp!"

She performed her Oscar-nominated song five times before leaving the theater. "It's been good, yeah?" she asked producer Neil Meron, who nodded in approval.

Just after Adele wrapped, the star-studded "Les Miserables" cast took the stage. Hathaway chatted with Bonham-Carter as Jackman sang a capella. Then Hathaway checked her microphone with a quick verse.

"Ooh, that was flat," she said.

The entire cast assembled for a final run-through when Jackman spontaneously began singing "My Bonny Lies over the Ocean."

"My bonny lies over my daddy," the ensemble responded, breaking into laughter.

Other stars rehearsing Friday included Jennifer Hudson, who is set to perform a song from "Dreamgirls" at Sunday's ceremony.

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AP Entertainment Writer Sandy Cohen is on Twitter: www.twitter.com/APSandy .

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16 airport investors show interest in Midway

An international array of airport investors and operators have shown interest in developing bids to privatize Midway Airport, the city announced Friday evening.

Sixteen parties responded to the city's "request for qualifications" by a 4 p.m. deadline, indicating they had interest in leasing, operating and improving the Southwest Side airport, the nation's 26th busiest, with about 9 million passengers passing through annually.

"The response generated from the  ... process is encouraging and provides the city with a sense of the strong level of interest in a potential lease," said Lois Scott, the city's chief financial officer. "We must evaluate fully if this could be a win for Chicagoans."

The city and its advisers will review the responses to identify qualified potential bidders.

Of the 16, seven had both the operational and financial capabilities sought in the RFQ. The city identified them as:

-- ACO Investment Group, an investor and operator with global airport experience.

-- AMP Capital Investors Limited, a manager and investor in airports, including Melbourne Airport in Australia and Newcastle Airport, in Britain.

--  Corporacion America Group, an Argentina-based airport operator with 49 airports in seven countries.

-- Global Infrastructure Partners (GIP), which is the controlling investor and active manager of London City Airport, London Gatwick Airport and Edinburgh Airport.

--Great Lakes Airport Alliance, which is a partnership of Macquarie Infrastructure and Real Assets and Ferrovial. Its airport operations include London's Heathrow, Brussels Airport and Copenhagen Airport.

-- Incheon International Airport and Hastings Funds Management, which is the sole owner and operator of Incheon International Airport in South Korea and an investor with 16 airport-related investments.

--  Industry Funds Management and Manchester Airport Group, an investor with interests in 13 airports, including Melbourne Airport and Brisbane Airport, both in Australia, and operator of Manchester Airport and East Midlands Airport, in Britain.

If the city moves forward and seeks proposals, a privatization plan could be submitted to the City Council this summer.

This is the second time Chicago has looked at privatizing Midway. A 99-year lease that would have brought in $2.5 billion died in 2009 when the financial markets froze. That deal had drawn six serious bidders.

Mayor Rahm Emanuel has said any second attempt would have to provide city taxpayers with a better deal than the widely criticized 75-year agreement to privatize parking meter operations, carried out during former Mayor Richard Daley's administration. Proceeds from the earlier deal were used to plug operating deficits, and meter rates rose sharply.

This time, proposed leases must be less than 40 years, which locks in the city for a shorter period.

Rather than making only an upfront payment, the private operator also must share revenue with the city on an ongoing basis. Initial proceeds would be used to pay down debt issued since 1996 to rebuild the airport, the mayor's office said. There is about $1.4 billion in outstanding debt.

Longer term, cash flow would be directed to city infrastructure needs. The mayor has pledged proceeds would not be used to pay for city operations.

kbergen@tribune.com

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Storm loses punch, but still socks morning commute

A winter storm that buried the Great Plains in more than a foot of snow lost some of its punch as it blew through Chicago overnight, but it still managed to slow the morning commute with slick roads and dozens of spinouts on expressways.

Snow began tapering off around 5:30 a.m., but the National Weather Service was warning of freezing drizzle through the morning and light snow in the afternoon. A winter weather advisory remains in effect until 6 p.m.

At 6 a.m., 2.7 inches had fallen at O'Hare International Airport, tying the highest total recorded there this winter, according to the National Weather Service. Accumulation ranged from 2 to 5 inches throughout the area, according to the Chicago Weather Center.

At the height of the storm shortly after midnight, state police described road conditions as "horrible." But conditions had improved by the time the morning rush hour began. Still, state police said they had responded to 22 accidents as of 7 a.m. but there were many other spinouts that didn't require their assistance.

The city of Chicago sent 284 plows to work clearing main thoroughfares, according to the Streets and Sanitation Department.

Dozens of schools closed because of the storm, or delayed start times.

The storm, which is moving toward the Northeast, has forced the cancellation of nearly 400 flights at O'Hare and delays for 80 more.

Flurries could linger into the weekend, with a chance for light snow on Saturday.  High temperatures both days should be around 30, with lows in the low 20s and high teens both mornings.

Kansas bore the brunt of the storm, with up to 15 inches of snow in some parts of the state, according to the National Weather Service. A 200-mile stretch of Interstate 70 in central Kansas was closed and strewn with cars stuck in snow.

National Guard troops riding in Humvees were dispatched to look for stranded motorists along the interstate and other highways, said Sharon Watson, a spokeswoman for Kansas emergency management services.

The fierce storm triggered severe thunderstorms from eastern Texas to Georgia. Thunder accompanied snow in Kansas City, hit by 2 to 3 inches of snow per hour on Thursday morning.

"When there is thunder and lightning, it's a pretty screaming clue that you are going to have massive snowfall," said Andy Bailey, a meteorologist with the National Weather Service in Pleasant Hill, Missouri.

Missouri Gov. Jay Nixon and Kansas Gov. Sam Brownback declared states of emergency because of hazardous travel and possible power outages. Brownback ordered state offices closed because of the storm.

Kansas City International Airport was closed on Thursday while crews cleared runways. It was unclear when the airport would reopen, spokesman Joe McBride said.

At the Denver International Airport, some 55 commuter flights were canceled overnight, spokeswoman Laura Coale said. More than 320 flights in and out of Lambert-St. Louis International Airport were scrapped and nearly 50 flights in and out of Omaha's Eppley Airfield were listed as canceled by midday.

In Nebraska, a 19-year-old woman was killed in a two-car accident on Wednesday on Interstate 80 near Giltner. The Nebraska State Patrol said weather was a factor.

An 18-year-old man died in Oklahoma when his vehicle slid into a semi-truck on a slushy state highway, the state's highway patrol said.

The storm is expected to reach the East Coast this weekend, delivering heavy snow to parts of New England for a third straight weekend, from northern Connecticut to southern Maine.

Reuters contributed

chicagobreaking@tribune.com

Twitter: @ChicagoBreaking

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EU sees Google competition deal after August

PARIS (Reuters) - EU regulators hope to resolve a two-year investigation into U.S. internet company Google in the latter half of the year, the EU's antitrust chief said on Friday, although a rival expressed skepticism about the effectiveness of any solution.

The European Commission - the EU's executive arm - has been examining proposals put forward by Google to resolve complaints from more than a dozen companies, including Microsoft, that Google was using its market dominance to block competitors.

"We can reach an agreement after the summer break. We can envisage this as a possible deadline," EU Competition Commissioner Joaquin Almunia told a Concurrences Journal conference.

The Commission is closed for its summer break for most of August.

Almunia said there would only be a decision "if everything was okay." Neither Google nor the EU antitrust authority have detailed what concessions the U.S. group has offered. If the EU authority accepts the offer, it would mean no fine for Google.

People familiar with the matter have previously told Reuters that Google offered to label its own services in search results to differentiate them from rival services, and also to impose fewer restrictions on advertisers.

The Commission is expected to seek feedback from Google rivals and other third parties once it completes its examination of the concessions.

However, British price comparison site and Google complainant Foundem had doubts about the efficacy of any proposals from the U.S. company.

"We will withhold judgment on Google's proposals until we have seen them, but everything we have learned about Google makes us sceptical that it would volunteer truly effective remedies until it has been formally charged with infringement," said Foundem Chief Executive Shivaun Raff.

The U.S. Federal Trade Commission last month ended its own investigation without any significant action, handing Google a major victory.

EU regulators have said Google may have favored its own search services over those of rivals, copied travel and restaurant reviews from competing sites without permission, and placed restrictions on advertisers and advertising.

(Editing by Dan Lalor and Mark Potter)

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Flu shot doing poor job of protecting older people

ATLANTA (AP) — It turns out this year's flu shot is doing a startlingly dismal job of protecting older people, the most vulnerable age group.

The vaccine is proving only 9 percent effective in those 65 and older against the harsh strain of the flu that is predominant this season, the Centers for Disease Control and Prevention said Thursday.

Health officials are baffled as to why this is so. But the findings help explain why so many older people have been hospitalized with the flu this year.

Despite the findings, the CDC stood by its recommendation that everyone over 6 months get flu shots, the elderly included, because some protection is better than none, and because those who are vaccinated and still get sick may suffer less severe symptoms.

"Year in and year out, the vaccine is the best protection we have," said CDC flu expert Dr. Joseph Bresee.

Overall, across the age groups studied, the vaccine's effectiveness was found to be a moderate 56 percent, which means those who got a shot have a 56 percent lower chance of winding up at the doctor with the flu. That is somewhat worse than what has been seen in other years.

For those 65 and older, the vaccine was only 27 percent effective against the three strains it is designed to protect against, the worst level in about a decade. It did a particularly poor job against the tough strain that is causing more than three-quarters of the illnesses this year.

It is well known that flu vaccine tends to protect younger people better than older ones. Elderly people have weaker immune systems that don't respond as well to flu shots, and they are more vulnerable to the illness and its complications, including pneumonia.

But health officials said they don't know why this year's vaccine did so poorly in that age group.

One theory, as yet unproven, is that older people's immune systems were accustomed to strains from the last two years and had more trouble switching gears to handle this year's different, harsh strain.

The preliminary data for senior citizens is less than definitive. It is based on fewer than 300 people scattered among five states.

But it will no doubt surprise many people that the effectiveness is that low, said Michael Osterholm, a University of Minnesota infectious-disease expert who has tried to draw attention to the need for a more effective flu vaccine.

Among infectious diseases, flu is considered one of the nation's leading killers. On average, about 24,000 Americans die each flu season, according to the CDC.

This flu season started in early December, a month earlier than usual, and peaked by the end of year. Hospitalization rates for people 65 and older have been some of the highest in a decade, at 146 per 100,000 people.

Flu viruses tend to mutate more quickly than others, so a new vaccine is formulated each year to target the strains expected to be the major threats. CDC officials have said that in formulating this year's vaccine, scientists accurately anticipated the strains that are circulating this season.

Because of the guesswork involved, scientists tend to set a lower bar for flu vaccine. While childhood vaccines against diseases like measles are expected to be 90 or 95 percent effective, a flu vaccine that's 60 to 70 percent effective in the U.S. is considered pretty good. By that standard, this year's vaccine is OK.

For senior citizens, a flu vaccine is considered pretty good if it's in the 30 to 40 percent range, said Dr. Arnold Monto, a University of Michigan flu expert.

A high-dose version of the flu shot was recently made available for those 65 and older, but the new study was too small to show whether that has made a difference.

The CDC estimates are based on about 2,700 people who got sick in December and January. The researchers traced back to see who had gotten shots and who hadn't. An earlier, smaller study put the vaccine's overall effectiveness at 62 percent, but other factors that might have influenced that figure weren't taken into account.

The CDC's Bresee said there is a danger in providing preliminary results because it may result in people doubting — or skipping — flu shots. But the figures were released to warn older people who got shots that they may still get sick and shouldn't ignore any serious flu-like symptoms, he said.

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Online:

CDC report: http://www.cdc.gov/mmwr

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Tyler, Perry lead Songwriters Hall of Fame class

NASHVILLE, Tenn. (AP) — The Songwriters Hall of Fame is saluting 1970s and '80s rock 'n' roll with its 2013 induction class.

Joe Perry and Steven Tyler of Aerosmith and Mick Jones and Lou Gramm of Foreigner will join the hall of fame this year along with the writers of iconic rock hits "Love Is a Battlefield" and "Heartache Tonight." The ceremony will be held June 13 in New York.

Aerosmith and Foreigner will get the attention here, but inductees Holly Knight, JD Souther and Tony Hatch also have distinguished careers that helped define the sound of rock 'n' roll.

Knight wrote anthemic hits "Love Is a Battlefield" and "Invincible" for Pat Benatar and "The Warrior" for Patty Smyth. She also wrote several songs for Tina Turner, including "The Best" and "Better Be Good to Me," that became standards for the star.

Souther, who has a role on the music-inspired television show "Nashville," had a partnership with The Eagles that spawned several hits, including "Heartache Tonight," ''Victim of Love," ''New Kid in Town" and "Best of My Love."

Hatch made his mark during the British invasion, teaming with Petula Clark on hits like "Downtown" and "My Love" that helped shaped the future of pop music.

Perry and Tyler have survived a sometimes contentious relationship to become one of rock's most successful songwriting teams over the last 40 years. The Rock and Roll Hall of Famers, staples of classic rock radio and pop culture icons, are known for hits like "Sweet Emotion," ''Dream On" and "Livin' on the Edge," and released their 15th studio album last year.

Jones and Gramm are contemporaries of Perry and Tyler who also ruled radio for a time, but they sometimes came at it from a different angle. They could lay down a straight-up rocker like "Jukebox Hero" or "Feels Like the First Time." But they also could slow it down with hits like "I Wanna Know What Love Is" and "Cold as Ice" that helped foreshadow the ballad-driven rock of the late '80s.

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Online:

http://songhall.org

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Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott .

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United not planning on Dreamliner until June

The All Nippon Airways Dreamliner 787 arrives at Mineta San Jose International Airport. (Gary Reyes/San Jose Mercury News/MCT / January 22, 2013)

Staff and wire report

1:35 p.m. CST, February 21, 2013

The parent company of United Airlines says it is taking the Boeing 787 off its schedule through June 5 for all but one of its routes.

United Continental Holdings Inc. said it still plans to use the 787 on its flights between Denver and Tokyo's Narita airport starting May 12. It had aimed to start that route on March 31.

United, currently world's largest airline and the only U.S. customer for the 787, said the timing of that reinstatement will depend on resolution of the Dreamliner's current issues.

The 50 Dreamliners in commercial service were grounded worldwide last month after a series of battery-related incidents including a fire on board a parked plane in the United States and an in-flight problem on another jet in Japan. United had only been flying the plance since November.

Sources told Reuters earlier this week that Boeing Co. has found a way to fix the battery problems that involves increasing the space between the lithium ion battery cells.

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Judge poised to rule in Drew Peterson case

Drew Peterson could be sentenced to up to 60 years in prison today if a judge rejects defense team arguments that his former lead attorney's inept trial performance violated his constitutional rights to a fair trial.

Judge Edward Burmila is expected to rule Thursday whether the former Bolingbrook police sergeant will get a new trial, a rarely granted motion.

If not, Burmila will begin a sentencing hearing at which prosecutors have said they plan to argue Peterson also killed his fourth wife, Stacy, who went missing in 2007, in asking for the maximum sentence.

Peterson, 59, was convicted by a jury last fall of first-degree murder in the 2004 bathtub drowning of his third wife, Kathleen Savio.

Among the oddities Wednesday, during the unusual hearing on post-trial motions that has stretched across two days, was former Peterson lead attorney Joel Brodsky chatting in a courthouse hallway with Stacy's sister Cassandra Cales.

Both declined to detail their conversation. “We were just discussing how to make sure that her sister Stacy isn't forgotten after Drew goes away,” Brodsky said.

Much of Wednesday's hearing focused on Brodsky's trial decision to call Wheaton divorce attorney Harry Smith, who represented Savio in her bitter divorce fight with Peterson and also fielded a call from Stacy about her divorce options shortly before she vanished.

Smith testified at trial that Stacy had asked him if the fact that Peterson killed his third wife could be used as leverage in a divorce.

Several jurors said after trial that the testimony convinced them of Peterson's guilt. There was no physical evidence tying Peterson to Savio's death, which was initially treated as an accident.

Retired Cook County Judge Daniel Locallo, called as a witness by Peterson's attorneys, blasted Brodsky for calling Smith, saying the testimony for the first time at trial connected Peterson to Savio's death.

The retired judge said that, in his opinion, Brodsky's decisions constituted ineffective assistance of counsel, which can be grounds for a new trial.

“It was an awful decision,” defense attorney Steve Greenberg later argued in court. “It ruined the case -- we brought out the worst possible evidence, and the best evidence for the state.”

The defense team also attempted to call to the stand Will County State's Attorney James Glasgow to explain his comment in a courthouse hallway during the trial that Smith's testimony was “a gift from God.”

Greenberg wanted to use the statement to contradict prosecutors' argument that Smith's testimony was part of well-thought-out defense strategy.

Burmila first called Glasgow to be sworn in, but stopped the process after prosecutors said Peterson had failed to meet the legal standards necessary to call him.

Assistant State's Attorney Marie Czech argued that Brodsky's decision to call Smith was a calculated risk to discredit Stacy by attempting to show she was out for money, and not grounds for a new trial.

“There was a strategic decision,” she argued. “It was well-conceived.”

Greenberg argued that the upside was so small and the risks so monumental that there was no way Brodsky's decision could have been part of a reasonable trial strategy.

“Whatever kernel of impeachment Mr. Brodsky thought he was going to get out of it paled in comparison to the mountain of damage that it brought out,” Greenberg said. “It was awful strategy, and that strategy alone means Mr. Peterson should get a new trial from this court.”

Brodsky, who could be heard sighing loudly as he listened to Wednesday's arguments in an overflow room, continued to assert that he was not alone in the decision to call Smith, saying Greenberg supported the decision.

“A number of lies and misrepresentations were made about me today, but you know, I've got tough skin,” Brodsky said. “I can handle that.”

Stacy's older sister Cales said she was “very excited” that Peterson could be sentenced Thursday.

“Even if he gets the minimum of 20 years, technically that's life for him because he's an old man,” she said.

Cales said that she still holds out hope that someone will come forward with information about her sister's disappearance. Prosecutors have said they are reviewing the case again with an eye to possibly bringing charges.

“Maybe that person out there will have a conscience and come forward because Drew will be away at prison and will be unable to hurt them,” Cales said.

mwalberg@tribune.com
sschmadeke@tribune.com

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